QUANTITATION OF NON-DERIVATIZED FREE AMINO ACIDS FOR DETECTING INBORN ERRORS OF METABOLISM BY INCORPORATING MIXED-MODE CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY

Quantitation of non-derivatized free amino acids for detecting inborn errors of metabolism by incorporating mixed-mode chromatography with tandem mass spectrometry

Introduction: Amino acids are critical biomarkers for many inborn errors of metabolism, but amino acid analysis is challenging due to the range of chemical properties inherent in these small molecules.Techniques are available for amino acid analysis, but they can suffer from long run times, laborious derivatization, and/or poor resolution of isobar

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Room-Temperature Solid-State Maser Amplifier

Masers once represented the state of the art in low-noise microwave amplification technology but eventually became obsolete due to their need for cryogenic cooling.Masers based on solid-state spin systems perform most effectively as amplifiers, since they provide a large density of spins and can, therefore, operate at relatively high powers.While s

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The complete mitochondrial genome of click beetle Chiagosnius sulcicollis (Coleoptera: Elateridae) and phylogenetic analysis

In this study, we determined the complete mitochondrial genome sequence of click beetle Chiagosnius sulcicollis (Candeze, 1878) (GenBank accession no.MK792747) using next-generation sequencing (NGS) method.The mitogenome is 15,848 bp in length, consisting of 13 protein-coding Universal Remote Control genes (PCGs), 2 ribosomal RNA genes, 22 transfer

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